ELK Biotechnology SRF (phospho Ser103) rabbit pAb
SRF (phospho Ser103) rabbit pAb는 세포 증식 및 분화 관련 SRF 단백질을 인식하는 인산화 특이 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며 인간, 생쥐, 랫트 반응성을 가집니다. 핵 내 위치 단백질 검출에 적합합니다.
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SRF (phospho Ser103) rabbit pAb
제품 개요
SRF (phospho Ser103) rabbit pAb는 인간 SRF 단백질의 Ser103 인산화 부위를 특이적으로 인식하는 폴리클로날 항체입니다. 세포 성장, 분화, 및 전사 조절 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SRF (phospho Ser103) rabbit pAb |
| Alternative Names | SRF; Serum response factor; SRF |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SRF around the phosphorylation site of Ser99 (AA range: 71–120) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 51 kD |
| Gene ID (Human) | 6722 |
| Human Swiss-Prot No | P11831 |
| Cellular localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. It regulates the activity of many immediate-early genes such as c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and differentiation. SRF acts downstream of several pathways, including the mitogen-activated protein kinase (MAPK) pathway via ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been identified (RefSeq, May 2014).
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