ELK Biotechnology SREBP-1 (phospho Ser439) rabbit pAb
SREBP-1 (phospho Ser439) rabbit polyclonal antibody로, 인간 및 랫트 시료에서 사용 가능. WB, IHC, IF, ELISA 등 다양한 응용에 적합. Ser439 인산화 부위 특이적 인식. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 안정적 보관.
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제품명
SREBP-1 (phospho Ser439) rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SREBP-1 around the phosphorylation site of Ser439 (AA range: 405–454) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 122 kD |
| GeneID (Human) | 6720 |
| Human Swiss-Prot No | P36956 |
| Species Reactivity | Human; Rat |
세포 내 위치 (Cellular Localization)
- Sterol regulatory element-binding protein 1: Endoplasmic reticulum membrane; multi-pass membrane protein.
- Golgi apparatus membrane: multi-pass membrane protein.
- Cytoplasmic vesicle, COPII-coated vesicle membrane: multi-pass membrane protein.
- High sterol concentrations: SCAP-SREBP retained in endoplasmic reticulum.
- Low sterol concentrations: recruitment into COPII-coated vesicles and transport to Golgi for processing.
- Processed SREBP-1: Nucleus.
- Isoform SREBP-1aDelta / SREBP-1cDelta: Nucleus.
배경 (Background)
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), a decamer flanking the low-density lipoprotein receptor gene and genes involved in sterol biosynthesis.
The precursor form is attached to the nuclear membrane and endoplasmic reticulum. After cleavage, the mature protein moves to the nucleus and activates transcription by binding to SRE1.
Sterols inhibit precursor cleavage, and the mature nuclear form is rapidly degraded, reducing transcription.
This protein belongs to the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
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