ELK Biotechnology BRCA1 (phospho Ser1457) rabbit pAb
BRCA1 단백질의 Ser1457 인산화 부위를 인식하는 rabbit polyclonal 항체. WB 및 ELISA에 적합하며, 인간, 랫드, 마우스에 반응. 핵 및 세포질에서 DNA 손상 반응 연구에 활용 가능. -20°C에서 1년 보관.
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BRCA1 (phospho Ser1457) rabbit pAb
제품 개요
BRCA1 단백질의 Ser1457 인산화 부위를 특이적으로 인식하는 rabbit polyclonal 항체입니다. DNA 손상 복구 및 종양 억제 기전 연구에 유용하며, Western blot 및 ELISA 분석에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | BRCA1 (phospho Ser1457) rabbit pAb |
| Alternative Names | BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1457 (AA range: 1423–1472) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kD |
| Gene ID (Human) | 672 |
| Human Swiss-Prot No. | P38398 |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). Isoform 3: Cytoplasm; Isoform 5: Cytoplasm. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form the BRCA1-associated genome surveillance complex (BASC). It associates with RNA polymerase II and histone deacetylase complexes, contributing to transcription regulation, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing modulates its subcellular localization and physiological function.
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