ELK Biotechnology BRCA1 (phospho Ser1423) rabbit pAb
BRCA1 인산화(Ser1423) 부위를 인식하는 토끼 폴리클로날 항체로, DNA 손상 반응 연구에 적합. WB, IHC, IF, ELISA에 사용 가능하며 핵 및 세포질 내 BRCA1 단백질 검출에 유용. 고순도 IgG, 1 mg/ml 농도, -20°C에서 장기 보관 가능.
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BRCA1 (phospho Ser1423) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | BRCA1 (phospho Ser1423) rabbit pAb |
| Alternative Names | BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1423 (AA range: 1391–1440) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 210 kDa |
| Gene ID (Human) | 672 |
| Human Swiss-Prot No | P38398 |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). Isoform 3 and 5: Cytoplasm. |
| Species Reactivity | Human; Rat |
Background
This gene encodes a nuclear phosphoprotein that plays a crucial role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein forms part of the BRCA1-associated genome surveillance complex (BASC), combining with other tumor suppressors, DNA damage sensors, and signal transducers. It associates with RNA polymerase II and interacts with histone deacetylase complexes through its C-terminal domain, contributing to transcription regulation, DNA double-strand break repair, and recombination. Mutations in this gene account for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects subcellular localization and function, generating multiple transcript variants.
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