ELK Biotechnology c-Src (phospho Ser75) rabbit pAb
c-Src 단백질의 Ser75 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며 다양한 종(Human, Mouse, Rat)에 반응. 세포 성장 및 암 관련 연구에 유용. -20°C에서 1년 보관 가능.
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제품명
c-Src (phospho Ser75) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SRC; SRC1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-src; p60-Src |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Src around the phosphorylation site of Ser75. AA range: 41–90 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 6714 |
| Human Swiss-Prot No. | P12931 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane; Lipid-anchor; Mitochondrion inner membrane; Nucleus; Cytoplasm (cytoskeleton, perinuclear region); Cell junction, focal adhesion.
Localizes to focal adhesion sites following integrin engagement (PubMed:22801373).
Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268).
Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596).
Background
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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