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ELK Biotechnology Synuclein-α (phospho Tyr133) rabbit pAb
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인간 Synuclein-α의 Tyr133 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 적합하며 다양한 종(Human, Mouse, Rat)에 반응. 파킨슨병 및 알츠하이머병 관련 연구에 활용 가능. -20°C 보관, 농도 1 mg/ml.
- 판매단위
- pk
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ELK Biotechnology ES7248-100UL Synuclein-α (phospho Tyr133) rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES7248-50UL Synuclein-α (phospho Tyr133) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Synuclein-α (phospho Tyr133) rabbit pAb
Synuclein-α (phospho Tyr133) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Synuclein-α (phospho Tyr133) rabbit pAb |
| Alternative Names | SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Synuclein-alpha around the phosphorylation site of Tyr133 (AA range: 91-140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15 kDa |
| GeneID (Human) | 6622 |
| Human Swiss-Prot No. | P37840 |
| Cellular Localization | Cytoplasm, membrane, nucleus, cell junction (synapse), secreted, axon projection. Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at varicosities (By similarity). |
| Species Reactivity | Human; Mouse; Rat |
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain, where alpha- and beta-synuclein selectively inhibit phospholipase D2. SNCA is involved in presynaptic signaling and membrane trafficking. Mutations or defects in SNCA are implicated in Parkinson’s disease, and SNCA peptides are major components of amyloid plaques in Alzheimer’s disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene (RefSeq, Feb 2016).
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