ELK Biotechnology SNAP 25 rabbit pAb
SNAP 25 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 25kDa 밴드 검출. 신경전달물질 방출 조절 연구에 적합. -20°C에서 1년 보관.
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제품명
SNAP 25 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SNAP25; SNAP; Synaptosomal-associated protein 25; SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SNAP25. AA range: 151-200 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kDa |
| Gene ID (Human) | 6616 |
| Human Swiss-Prot No. | P60880 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, perinuclear region; Cell membrane; Lipid-anchor; Cell junction, synapse, synaptosome; Photoreceptor inner segment. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 and PLCL1 at the cell membrane (By similarity). |
Background
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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