ELK Biotechnology Bmx (phospho Tyr40) rabbit pAb
인간 및 마우스 반응성을 가진 Bmx (phospho Tyr40) rabbit polyclonal antibody. Western blot, IHC, IF, ELISA에 적합하며 Tyr40 인산화 부위 기반 면역원 사용. 세포질에 위치하며 신호전달 및 암세포 분화 연구에 활용 가능.
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제품명
Bmx (phospho Tyr40) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ETK around the phosphorylation site of Tyr40. AA range: 6-55 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 78 kD |
| GeneID (Human) | 660 |
| Human Swiss-Prot No | P51813 |
| Cellular Localization | Cytoplasm. Localizes to the edges of spreading cells when complexed with BCAR1. |
| Species Reactivity | Human; Mouse |
배경 (Background)
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction.
The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells.
Alternatively spliced transcript variants have been found for this gene.
[provided by RefSeq, Mar 2016]
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