ELK Biotechnology Bmx (phospho Tyr566) rabbit pAb
Bmx (phospho Tyr566) rabbit pAb는 인산화 Tyr566 부위를 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 및 마우스 반응성이 있으며, 세포 신호전달 연구 및 암 관련 단백질 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
- 카탈로그번호
- ES7240-xxxxx (2개 옵션)
- 판매단위
- pk
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제품명
Bmx (phospho Tyr566) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
본 항체는 인간 ETK의 인산화 Tyr566 부위를 인식하도록 제작된 rabbit polyclonal antibody입니다. 세포 신호전달 및 암 관련 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | BMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human ETK around the phosphorylation site of Tyr566 (AA range: 532–581) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 78 kD |
| GeneID (Human) | 660 |
| Human Swiss-Prot No | P51813 |
| Cellular Localization | Cytoplasm. Localizes to the edges of spreading cells when complexed with BCAR1. |
| Storage | -20°C, 1 year |
| Host Species | Rabbit |
Background
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. It is involved in several signal transduction pathways including the Stat pathway and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. (RefSeq, Mar 2016)
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