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ELK Biotechnology Tensin3 rabbit pAb
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ELK Biotechnology Tensin3 rabbit pAb

상품 한눈에 보기

Tensin3 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, IF, ELISA 등에 사용 가능. 인간, 랫, 마우스에 반응하며 세포 이동 및 골 발달 관련 연구에 적합. -20°C에서 1년 보관 가능.

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ELK Biotechnology ES7196-100UL Tensin3 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES7196-50UL Tensin3 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology Tensin3 rabbit pAb

Tensin3 rabbit pAb

제품 개요

ELK Biotechnology에서 제공하는 Tensin3 rabbit polyclonal antibody는 인간 TNS3 단백질을 인식하도록 제작된 항체로, 세포 이동 및 골 발달 등 다양한 생물학적 과정 연구에 활용됩니다.

제품 사양

항목 내용
Product name Tensin3 rabbit pAb
Alternative Names TNS3; TEM6; TENS1; TPP; Tensin-3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6
Applications IHC; IF; ELISA
Recommended Dilutions Immunohistochemistry: 1/100 - 1/300
Immunofluorescence: 1/200 - 1/1000
ELISA: 1/20000
Not yet tested in other applications
Immunogen Synthesized peptide derived from human TENS3 (AA range: 541–590)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
GeneID (Human) 64759
Human Swiss-Prot No Q68CZ2
Cellular Localization Cell junction, focal adhesion
Species Reactivity Human; Rat; Mouse

Background

  • Function: May play a role in actin remodeling and in dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3, leading to capping of ITGB1 tail. Involved in mammary cell migration, cell migration, and bone development.
  • Induction: EGF induces down-regulation.
  • Post-translational modification (PTM): EGF induces tyrosine phosphorylation in a time- and dose-dependent manner.
  • Similarity: Contains 1 C2 tensin-type domain, 1 phosphatase tensin-type domain, and 1 SH2 domain.
  • Subunit Interaction: EGF promotes interaction with EGFR; interacts with PTK2 and BCAR1; tyrosine phosphorylation is critical for these interactions.
  • Tissue Specificity: Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts (protein level). Highly expressed in thyroid, kidney, and placenta; low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells; expression down-regulated in thyroid tumor tissues and anaplastic carcinomas.

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