Thermo Fisher Scientific CtIP Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
ELECEEDVIP DSPITAFSFS GVNRLRRKEN PHVRYIEQTH TKLEHSVCAN EMRKVSKSST HPQHNPNENE ILVADTYDQS QSPMAKAHGT SSYTPDKS

Target Information

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains, suggesting that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210–215 (2000)) showed that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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