Thermo Fisher Scientific CtIP Polyclonal Antibody
CtIP 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합. 인간 시료 반응성, 항원 친화 크로마토그래피 정제, 안정적인 액상 형태로 장기 보관 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RBBP8. Recombinant protein control fragment (Product #RP-98229). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790633 |
Product Specific Information
Immunogen sequence:
ELECEEDVIP DSPITAFSFS GVNRLRRKEN PHVRYIEQTH TKLEHSVCAN EMRKVSKSST HPQHNPNENE ILVADTYDQS QSPMAKAHGT SSYTPDKS
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains, suggesting that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210–215 (2000)) showed that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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