Thermo Fisher Scientific Human TFF-3 Recombinant Protein, PeproTech
인체 TFF-3 재조합 단백질로, 점막 치유 및 세포 이동 연구에 사용됩니다. E. coli 발현 시스템에서 생산되며, ≥98% 순도와 낮은 엔도톡신 수준을 갖습니다. 기능적 활성은 MCF-7 세포의 화학유인능으로 검증되었습니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications
Miscellaneous PubMed (Misc)
- Refer to publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse |
| Expression System | E. coli |
| Amino acid sequence | EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF |
| Molecular weight | 13.2 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% (SDS-PAGE gel and HPLC analyses) |
| Endotoxin concentration | <1 EU/µg |
| Activity | Chemoattracts human MCF-7 cells (1.0–10.0 µg/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient |
Product Specific Information
Recombinant Human TFF-3 is a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Trefoil peptides are protease-resistant molecules secreted throughout the gut that play a role in mucosal healing. They contain three intrachain disulfide bonds forming the trefoil motif (P-domain) and are clustered on human chromosome 21q22.3.
Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells lining mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may promote cell migration during healing processes. It is involved in the maintenance and repair of the intestinal mucosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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