Thermo Fisher Scientific IGF2BP3 Monoclonal Antibody (OTI7B10)
IGF2BP3 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC/IF, RIP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| RNA Immunoprecipitation (RIP) | 2.5 µg/10^6 cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B10 |
| Immunogen | Full length human recombinant protein of IGF2BP3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723272 |
Target Information
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies.
IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present. It is expressed in a significantly higher proportion of melanomas than Spitz nevi, and in metastatic melanomas significantly more than in thin melanomas.
IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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