Thermo Fisher Scientific ALDH18A1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ALDH18A1. Recombinant protein control fragment (Product #RP-89746). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ALDH18A1,uniProtId:P54886-1,ncbiNodeId:9606,antigenRange:97-245,antigenLength:795,antigenImageFileName:PA5-52546_ALDH18A1_P54886-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52546_ALDH18A1_P54886-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2637836

Product Specific Information

Immunogen sequence: SIVEQVSVLQ NQGREMMLVT SGAVAFGKQR LRHEILLSQS VRQALHSGQN QLKEMAIPVL EARACAAAGQ SGLMALYEAM FTQYSICAAQ ILVTNLDFHD EQKRRNLNGT LHELLRMNIV PIVNTNDAVV PPAEPNSDLQ GVNVISVKD

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.