Thermo Fisher Scientific ALDH18A1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL
• View publication

Product Specifications

Product Specific Information

Immunogen sequence:
SIVEQVSVLQ NQGREMMLVT SGAVAFGKQR LRHEILLSQS VRQALHSGQN QLKEMAIPVL EARACAAAGQ SGLMALYEAM FTQYSICAAQ ILVTNLDFHD EQKRRNLNGT LHELLRMNIV PIVNTNDAVV PPAEPNSDLQ GVNVISVKD

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 99%
  • Rat: 99%

Target Information

This gene belongs to the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities.
The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine, and arginine.
Mutations in this gene can lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia, and hypoprolinemia, and may be associated with neurodegeneration, cataracts, and connective tissue diseases.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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