Thermo Fisher Scientific DOK6 Polyclonal Antibody
Rabbit polyclonal antibody against human DOK6 protein. Validated for IHC (Paraffin) with high specificity. Suitable for CNS development and Ret signaling studies. Supplied as liquid form, 0.3 mg/mL, stored at 4°C or -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DOK6. Recombinant protein control fragment (Product # RP-98284) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640746 |
Product Specific Information
Immunogen sequence:
WHHITRQNSV GEIYSLQGHG FGSSKMSRAQ TFPSYAPEQS EEAQQPLSRS SSYGFSYSSS LIQ
Ortholog sequence identity:
- Mouse: 98%
- Rat: 98%
Target Information
DOK-6 (Docking Protein 6) is a member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. It is highly expressed in the developing central nervous system and co-expressed with Ret in sympathetic, sensory, and parasympathetic ganglia, as well as in ureteric buds of developing kidneys.
Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Ligand activation of Ret results in phosphorylation of tyrosine residues within the C terminus of Dok-6 through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway.
Reference: Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072–81.
Also known as: DOK6, HsT3226, MGC20785, IRS
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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