ELK Biotechnology Trk A (Phospho-Y496) Antibody
Trk A (Phospho-Y496) 인산화 항체로, 인간·마우스·랫트 시료에 반응합니다. WB, IF, ELISA에 적합하며 세포막 및 엔도솜에서 발현되는 TrkA 단백질 검출에 활용됩니다. 폴리클로날 Rabbit IgG로, -20°C에서 1년 보관 가능합니다.
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Trk A (Phospho-Y496) Antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Trk A (Phospho-Y496) Antibody |
| Alternative Names | High affinity nerve growth factor receptor (EC 2.7.10.1); Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | WB 1:500–2000; IF/ICC 1:100–500; ELISA 1:5000–20000 |
| Immunogen | Synthesized phospho peptide derived from human Trk A (Phospho-Y496) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kD |
| GeneID (Human) | 4914 |
| Human Swiss-Prot No. | P04629 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Early, late, and recycling endosome membrane. Rapidly internalized after NGF binding and transported via retrograde axonal transport. Colocalized with RAPGEF2 at late endosomes. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation, and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. (RefSeq, Jul 2008)
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