ELK Biotechnology TRY2 rabbit pAb
Human, rat, mouse에서 반응하는 TRY2 rabbit polyclonal antibody로 IHC, IF, WB에 적합. 인간 TRY2 유래 펩타이드로 면역화되어 27kD 밴드를 검출. -20°C에서 1년 보관 가능하며, 세포외 분비 단백질 검출에 유용.
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제품명
TRY2 rabbit pAb
제품 개요
TRY2 rabbit polyclonal antibody는 인간 TRY2 단백질을 인식하도록 제작된 항체로, 다양한 종에서 반응성을 보이며 IHC, IF, WB 실험에 사용됩니다.
제품 상세 정보
| 항목 | 내용 |
|---|---|
| Product name | TRY2 rabbit pAb |
| Alternative Names | Trypsin-2 (EC 3.4.21.4; Anionic trypsinogen; Serine protease 2; Trypsin II) |
| Applications | IHC; IF; WB |
| Recommended Dilutions | IHC-p 1:50–200, WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human TRY2 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 27 kD |
| GeneID (Human) | 5645 |
| Human Swiss-Prot No | P07478 |
| Cellular Localization | Secreted, extracellular space |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds following lysine or arginine residues. This protein is highly expressed in pancreatic juice and is upregulated in pancreatitis. It can activate pro-urokinase in ovarian tumors, suggesting a role in tumor invasion. Additionally, it can cleave the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially contributing to cartilage matrix degradation. Alternative splicing results in multiple transcript variants. [RefSeq, Jan 2015]
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