ELK Biotechnology TULP3 rabbit pAb
TULP3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 실험에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막과 핵 등 다양한 세포소기관에서 발현된 TULP3 검출에 유용합니다. -20°C에서 1년간 보관 가능합니다.
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제품명
TULP3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human TULP3 (AA 257–307) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 7289 |
| Human Swiss-Prot No. | O75386 |
| Species Reactivity | Human, Mouse |
| Cellular Localization | Nucleus, Cell membrane, Cell projection (cilium), Cytoplasm, Secreted. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. |
Background
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region.
The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling.
It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene.
[Provided by RefSeq, May 2009]
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