ELK Biotechnology VP33B rabbit pAb

ELK Biotechnology VP33B rabbit pAb

제품 개요

VP33B rabbit pAb는 인간 VP33B 단백질에서 유래한 합성 펩타이드(AA 12–62)를 면역원으로 제작된 다클론 항체입니다. 세포 내 소기관 및 단백질 분류 연구에 활용됩니다.

제품 정보

세포 내 위치

Late endosome membrane, peripheral membrane protein, cytoplasmic side. Lysosome membrane, peripheral membrane protein, cytoplasmic side. Early endosome, cytoplasmic vesicle, clathrin-coated vesicle, recycling endosome. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5, and Rab7b (PubMed:21411634). Colocalizes with M. tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358).

Background

Vesicle-mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]