ELK Biotechnology WHRN rabbit pAb

제품명

WHRN rabbit pAb

제품 개요

WHRN 단백질을 표적하는 토끼 폴리클로날 항체로, 웨스턴 블롯(WB) 실험에 적합합니다. 인간, 생쥐, 랫드에서 반응성이 확인되었습니다.

제품 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cell projection (stereocilium, growth cone), photoreceptor inner segment, cell junction (synapse).
Detected at the level of stereocilia in inner and outer hair cells of the cochlea and vestibule.
Localizes to both tip and ankle-link stereocilia regions.
Colocalizes with the growing ends of actin filaments and with MPP1 in the retina (OLM, OPL, basal bodies, connecting cilium).
In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment surrounding the connecting cilia (periciliary membrane complex).

배경 (Background)

This gene is involved in the organization and stabilization of stereocilia elongation and actin cytoskeletal assembly, based on studies of the related mouse gene.
Mutations in this gene are associated with autosomal recessive non-syndromic deafness and Usher Syndrome.
Alternative splicing results in multiple transcript variants encoding different isoforms.
(Provided by RefSeq, Mar 2010)