ELK Biotechnology TAP1 rabbit pAb
TAP1 단백질을 인식하는 토끼 폴리클로날 항체로 WB 및 ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 IgG 형태로 -20°C에서 1년간 안정적 보관. ATP-binding cassette 수송체 관련 연구에 적합.
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TAP1 rabbit pAb
제품 개요
ELK Biotechnology에서 제공하는 TAP1 rabbit pAb는 ATP-binding cassette(ABC) 수송체 슈퍼패밀리의 TAP1 단백질을 인식하는 폴리클로날 항체입니다. WB 및 ELISA 분석에 적합하며, 인간, 생쥐, 랫트 시료에서 반응성을 보입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TAP1 rabbit pAb |
| Applications | WB, ELISA |
| Recommended Dilutions | WB: 1:500–2000 / ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 88 kD |
| GeneID (Human) | 6890 |
| Human Swiss-Prot No | Q03518 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane. |
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily, which is involved in multidrug resistance. The protein encoded by this gene is responsible for pumping degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
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