ELK Biotechnology I23O1 rabbit pAb
인돌아민 2,3-디옥시게나아제(IDO) 단백질을 인식하는 토끼 폴리클로날 항체. WB와 ELISA에 적합하며, 사람·마우스·랫트 시료에 반응. 세포질에 위치한 단백질 검출용으로 사용. -20°C에서 1년 보관 가능.
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제품명
I23O1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| Gene ID (Human) | 3620 |
| Human Swiss-Prot No. | P14902 |
| Cellular Localization | Cytoplasm, cytosol |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes indoleamine 2,3-dioxygenase (IDO), a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine.
This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin.
It is involved in various pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity.
Through its expression in dendritic cells, monocytes, and macrophages, this enzyme modulates T-cell behavior by pericellular catabolization of the essential amino acid tryptophan.
[provided by RefSeq, Feb 2011]
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