ELK Biotechnology SPY2 rabbit pAb
SPY2 rabbit pAb는 인간 및 마우스 단백질 검출용 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 고순도 IgG 형태로 1 mg/ml 농도이며, -20°C에서 1년 보관 가능합니다. 세포막 및 세포골격 관련 단백질 연구에 활용됩니다.
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제품명
SPY2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| GeneID (Human) | 10253 |
| Human Swiss-Prot No | O43597 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm, cytoskeleton, cell projection, ruffle membrane. Associated with microtubules in unstimulated cells but translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
배경 (Background)
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for inhibitory activity on receptor tyrosine kinase signaling and is required for growth factor–stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells, this gene is transiently upregulated in response to fibroblast growth factor 2. This protein indirectly contributes to the non-cell autonomous inhibitory effect on fibroblast growth factor 2 signaling. It interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence and functions as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. It may play a role in alveoli branching during lung development, as shown by a similar mouse protein.
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