ELK Biotechnology ENPP1 rabbit pAb

제품명

ENPP1 rabbit pAb

제품 설명

ENPP1 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. Western blot(WB) 및 ELISA 실험에 사용되며, 인간, 마우스, 랫트 시료에서 반응합니다. ENPP1은 세포막에 위치하는 type II 막단백질로, 다양한 뉴클레오타이드 및 피로인산 결합을 절단하는 효소 활성을 가집니다.

제품 정보

세포 내 위치

• Ectonucleotide pyrophosphatase/phosphodiesterase family member 1:
  Cell membrane; single-pass type II membrane protein. Basolateral cell membrane; targeted to the basolateral membrane in polarized epithelial cells and hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187).
  In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187).

• Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form:
  Secreted following proteolytic cleavage.

Background

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad substrate specificity and cleaves phosphodiester and pyrophosphate bonds of nucleotides and nucleotide sugars. It may function to hydrolyze nucleoside 5′ triphosphates to monophosphates and diadenosine polyphosphates.
Mutations in this gene have been associated with idiopathic infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [RefSeq, Jul 2008]