ELK Biotechnology MYH9 rabbit pAb
MYH9 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며 세포골격 관련 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
MYH9 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 215 kD |
| Gene ID (Human) | 4627 |
| Human Swiss-Prot No | P35579 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, cytoskeleton, cytoplasm cell cortex, cytoplasmic vesicle, secretory vesicle, cortical granule.
Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411).
In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610).
배경 (Background)
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B).
The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain, which is involved in several important functions including cytokinesis, cell motility, and maintenance of cell shape.
Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome, and macrothrombocytopenia with progressive sensorineural deafness.
[provided by RefSeq, Dec 2011]
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