ELK Biotechnology IDH3G rabbit pAb

ELK Biotechnology IDH3G rabbit pAb

제품 설명

IDH3G rabbit pAb는 인간 IDH3G 단백질을 인식하는 폴리클로날 항체로, Western Blot(WB) 및 ELISA 실험에 적합합니다. 본 항체는 합성된 인간 단백질의 부분 펩타이드로부터 유래되었으며, 미토콘드리아에 위치한 NAD(+)-의존성 이소시트르산 탈수소효소 감마 소단위체를 검출하는 데 사용됩니다.

제품 정보

Background

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.