ELK Biotechnology GSTM1 rabbit pAb

GSTM1 rabbit pAb

제품 정보

Background

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, which functions in detoxification of electrophilic compounds including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products by conjugation with glutathione.
The mu class genes are organized in a cluster on chromosome 1p13.3 and are highly polymorphic, influencing susceptibility to toxins and drug response. Null mutations in this class can affect enzyme activity and individual detoxification capacity.