ELK Biotechnology DNMT1 rabbit pAb
DNMT1 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 핵 내 DNMT1 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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DNMT1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DNMT1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 177 kD |
| Gene ID (Human) | 1786 |
| Human Swiss-Prot No | P26358 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, narcolepsy, and hereditary sensory neuropathy type IE. Alternative splicing results in multiple transcript variants.
[Provided by RefSeq, Jan 2016]
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