Thermo Fisher Scientific Mouse SCF, AOF Recombinant Protein

Thermo Fisher Scientific Mouse SCF, AOF Recombinant Protein

Applications

• Assay-dependent
• Suitable for research on c-Kit signaling and inflammatory responses

Product Specifications

Product Specific Information

• Animal Origin Free (AOF)
• Reconstitute with sterile water to 0.1 mg/mL concentration

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF promotes mast cell survival and triggers histamine and cytokine release. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.

Usage Notes

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.