Thermo Fisher Scientific BARD1 Polyclonal Antibody
BRCA1과 상호작용하는 인간 BARD1 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot 및 Immunoprecipitation에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. 4°C 보관, 1년 권장 유효기간.
- 카탈로그번호
- A300263Ax (2개 옵션)
- 판매단위
- pk
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2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific BARD1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,500 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 250 and 300 of human BRCA1-associated RING Domain 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes a protein that interacts with the N-terminal region of BRCA1. It shares homology with two conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in various proteins that regulate cell growth, including tumor suppressor gene products and proto-oncogenes.
BARD1 also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, suggesting that the formation of a stable complex between these proteins is essential for BRCA1 tumor suppression. This protein may be a target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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