Thermo Fisher Scientific ABCC5 Monoclonal Antibody (OTI5A8), TrueMAB
Human ABCC5 단백질을 인식하는 Mouse monoclonal antibody. Western blot에 최적화된 TrueMAB 형식. E.coli에서 발현된 full-length recombinant protein을 면역원으로 사용. 1 mg/mL 농도의 액상 제품으로, -20°C에서 보관. 연구용 전용 시약.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A8 |
| Immunogen | Full length human recombinant protein of human ABCC5 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the ABCC5 gene is a member of the ATP-binding cassette (ABC) transporter superfamily. These proteins transport various molecules across extra- and intracellular membranes.
ABCC5 belongs to the MRP subfamily, which is associated with multi-drug resistance. It functions in the cellular export of cyclic nucleotides, contributing to their degradation and elimination.
This protein confers resistance to thiopurine anticancer drugs (6-mercaptopurine, thioguanine) and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. It may play a role in resistance to thiopurines in acute lymphoblastic leukemia and to antiretroviral nucleoside analogs in HIV-infected patients.
Alternative splicing of this gene has been detected, though the complete sequence and translation initiation site remain unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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