Thermo Fisher Scientific GFI1 Monoclonal Antibody (OTI4E2), TrueMAB
인간 GFI1 단백질에 특이적인 단클론 항체로 Western blot 분석에 적합합니다. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도로 사용 가능합니다. PBS(pH 7.3, 8% 트레할로스) 완충액에 보관하며, 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:2,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–180 of human GFI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
GFI1 is a nuclear zinc finger (ZF) transcriptional repressor involved in hematopoiesis and inner ear development, and is implicated in lymphomagenesis.
Gfi1 protein expression is regulated by the ubiquitin-proteasome system. The ubiquitin ligase Triad1 interacts with the DNA-binding domain of Gfi-1.
Gfi-1 represses transcription by binding directly to the consensus DNA sequence in target gene promoters.
Deficiency of Gfi-1 leads to neutropenia and accumulation of granulomonocytic precursor cells, resembling myelodysplastic syndrome in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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