Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI1G6), TrueMAB
Human TIM-3(HAVCR2) 단백질을 인식하는 Mouse IgG2a 단클론 항체. Western blot과 Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제. PBS/BSA/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G6 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid long, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
It is involved in macrophage activation and induction of autoimmune diseases, down-regulates aggressive Th1-mediated immune responses, and facilitates immune tolerance development.
Pathological significance of TIM3 has been attributed to Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease, where it enhances disease severity in mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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