Thermo Fisher Scientific PD-L2/PDCD1LG2/CD273 Monoclonal Antibody (PDL2/1850)

Applications

• Flow Cytometry (Flow): 1–2 µg/10⁶ cells

Product Specifications

Target Information

Programmed death-ligand 2 (PD-L2), also known as B7-DC, is a member of the B7 ligand family within the immunoglobulin superfamily. Along with PD-L1, it serves as a ligand for PD-1, an inhibitory immune checkpoint molecule. PD-L2 is primarily expressed in dendritic cells but can also be induced in various immune and non-immune cells depending on the microenvironment.

Its expression is upregulated by Th2 cytokine IL-4 and, to a lesser extent, by Th1 cytokines TNF-alpha and IFN-gamma. Although generally expressed at lower levels than PD-L1, PD-L2 exhibits 2–6 times higher affinity to PD-1. Binding of PD-L2 or PD-L1 to PD-1 inhibits T cell activation, proliferation, and cytokine secretion (e.g., IFN-gamma, IL-10), thereby modulating immune responses.

Recent studies suggest PD-L2 can also interact with repulsive guidance molecule b (RGMb), regulating respiratory tolerance via BMP and neogenin signaling pathways. The human PD-L2 monomer consists of a 201-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 32-amino-acid cytoplasmic domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.