Thermo Fisher Scientific PROX1 Polyclonal Antibody
Western blot, IHC, Flow cytometry에 사용 가능한 PROX1 다클론 항체로, Rabbit IgG 기반이며 Human과 Mouse에 반응합니다. Protein A 및 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.09% sodium azide가 포함되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 492–520 amino acids from human PROX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2543670 |
Target Information
The expression pattern of the Prox1 homeobox gene suggests that it plays a role in various embryonic tissues, including the lens. Prox1 mRNA is present in many human tissues, with the highest expression in the lens. Homozygous Prox1- mice die at midgestation due to developmental defects, particularly affecting lens development. Prox1 inactivation leads to abnormal cell proliferation, downregulation of Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis, resulting in defective lens formation.
Prox1 is expressed in endothelial cells that contribute to lymphatic system formation and acts as a key regulator of lymphatic development. It is also required for hepatocyte migration in mice; loss of Prox1 results in smaller livers with reduced hepatocyte clustering. In the embryonic mouse retina, Prox1 regulates progenitor cell cycle exit, influencing proliferation and cell fate determination.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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