Thermo Fisher Scientific TFAM Recombinant Rabbit Monoclonal Antibody (4H2M9)
TFAM 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, ELISA 등에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며, HEK293 세포에서 발현된 IgG 형식입니다. 미토콘드리아 DNA 유지 및 발현 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4H2M9 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 100–200 of human TFAM (NP_003192.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849266 |
Product Specific Information
Immunogen sequence:
QDAYRAEWQV YKEEISRFKE QLTPSQIMSL EKEIMDKHLK RKAMTKKKEL TLLGKPKRPR SAYNVYVAER FQEAKGDSPQ EKLKTVKENW KNLSDSEKEL Y
Target Information
Mitochondrial transcription factor A (TFAM) is a crucial protein encoded by nuclear genes but transported to mitochondria, where it maintains and expresses mitochondrial DNA (mtDNA). It regulates mtDNA replication and transcription, ensuring mitochondrial function. TFAM contains an LC3 interacting region (LIR) motif that binds autophagy proteins such as LC3, supporting the autolysosomal pathway to remove leaked mtDNA and limit inflammation.
TFAM levels vary across tissues, influencing mitochondrial function. Elevated levels can repress mtDNA expression in skeletal muscle, affecting oxidative phosphorylation (OXPHOS), while in cardiac tissue, balanced TFAM-to-mtDNA ratios preserve OXPHOS capacity. TFAM is essential for mitochondrial genome packaging, stability, and replication, and its dysregulation is linked to neurodegeneration and mtDNA stress-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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