Thermo Fisher Scientific Cytokeratin pan (Epithelial Marker) Recombinant Superclonal Antibody
인간 세포에서 광범위한 사이토케라틴(Type I/II)을 인식하는 재조합 슈퍼클로날 항체. 다양한 암 연구 및 조직학적 분석에 적합. 높은 민감도로 상피세포 및 암종 식별에 활용 가능. WB, IHC, ICC, Flow Cytometry 등 다중 응용 가능.
- 카탈로그번호
- RBP35-1835-P1NEO
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Cytokeratin pan (Epithelial Marker) Recombinant Superclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–3 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Superclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human KRT76 and KRT77 proteins |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Skin, Adeno- or Squamous carcinomas
- Cellular Localization: Cytoplasmic
Specificity Comments:
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including CK1 (67 kDa), CK3 (64 kDa), CK4 (59 kDa), CK5 (58 kDa), CK6 (56 kDa), CK8 (52 kDa), CK10 (56.5 kDa), CK14 (50 kDa), CK15 (50 kDa), CK16 (48 kDa), CK19 (40 kDa).
This broad-spectrum anti-pan-cytokeratin antibody differentiates epithelial from non-epithelial tumors (e.g., squamous vs. adeno carcinoma of lung, liver carcinoma, breast cancer, and esophageal cancer).
It is useful for characterizing neoplasm origin and studying cytokeratin distribution in normal and pathological epithelia.
Shows broad species reactivity.
Target Information
Cytokeratin pan is a subfamily of intermediate filament proteins found in human epithelial tissues, comprising at least 20 distinct polypeptides.
- Molecular weight range: 40–68 kDa
- Isoelectric point range: pH 4.9–7.8
Cytokeratin subtype expression reflects epithelial type and differentiation stage. These markers are valuable in distinguishing epithelial malignancies and aid in tumor diagnosis using immunohistochemistry, cytopathology, and flow cytometry.
Cytokeratin pair composition varies with cell type, differentiation, growth conditions, and disease state.
Widely used in cancer research and tumor diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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