Thermo Fisher Scientific DC-SIGN Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes a transmembrane receptor commonly referred to as DC-SIGN, expressed on the surface of dendritic cells and macrophages. The encoded protein participates in the innate immune system and recognizes a wide range of pathogens, including parasites and viruses.
The protein structure includes:

• N-terminal transmembrane domain
• Tandem-repeat neck domain
• C-type lectin carbohydrate recognition domain

The extracellular region functions as both a pathogen recognition receptor and a cell adhesion receptor, binding carbohydrate ligands on microbial and host cell surfaces. The neck region enables homo-oligomerization, allowing high-avidity binding to multivalent ligands.
Variations in the neck domain’s amino acid repeats can affect ligand-binding ability. DC-SIGN is closely related to L-SIGN (GeneID 10332) but differs in binding properties and tissue distribution.
Alternative splicing generates multiple variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.