Thermo Fisher Scientific MKNK1 Monoclonal Antibody (3E1)

Thermo Fisher Scientific MKNK1 Monoclonal Antibody (3E1)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Sequence of MKNK1 protein:
MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQRNKNILEL IEFFEDDTRF YLVFEKLQGG SILAHIQKQK HFNEREASRV VRGVAAALDF LHTKDKVSLC HLGWSAMAPS GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR LLSQHEENEL AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL

Target Information

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, acting as an eIF-4E kinase in vivo. Mnk2 may play a role in cellular stress and cytokine responses. Active MNK1/MNK2 mutants reduce cap-dependent translation relative to cap-independent translation. Human Mnk2 is homologous to murine Mnk2 (≈94% identity) and human Mnk1 (71% identity). In vitro phosphorylation studies show Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.