Thermo Fisher Scientific E4F1 Polyclonal Antibody
Thermo Fisher Scientific의 E4F1 Polyclonal Antibody는 인간 E4F1 단백질(275-325 aa)을 인식하는 토끼 IgG 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 275 and 325 of human E4F1 (p120E4F) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
E4F1 may function as a transcriptional repressor and as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. It plays a role in cell survival and proliferation through control of the cell cycle, participating in the p53 and pRB tumor suppressor pathways and regulating cyclin CCNA2 transcription.
Identified as a cellular target of the adenoviral oncoprotein E1A, E4F1 is required for both transcriptional activation and repression of viral genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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