Thermo Fisher Scientific GNA13 Polyclonal Antibody
GNA13 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 최적화됨. Human 시료에 반응하며, 합성 펩타이드(N-말단 aa 39–88)로부터 제작. 액상 형태, 0.5 mg/mL 농도, PBS(2% sucrose) 버퍼에 보관. -20°C에서 보관, 동결/해동 반복 회피.
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Applications
- Western Blot (WB): 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human GNA13 (aa 39–88) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607862 |
Product Specific Information
Peptide sequence:
SREKTYVKRL VKILLLGAGE SGKSTFLKQM RIIHGQDFDQ RAREEFRPTI
Target Information
Guanine nucleotide-binding proteins (G proteins) act as modulators or transducers in various transmembrane signaling systems. GNA13 activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF, and ARHGEF12/LARG).
GNA13-dependent Rho signaling regulates transcription factor AP-1 and promotes tumor cell invasion and metastasis via the RhoA/ROCK pathway. It also inhibits CDH1-mediated cell adhesion independently of Rho activation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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