Thermo Fisher Scientific TRIM28 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:2,000.

Target Information

The KRAB (Kruppel-associated box) domain is approximately 45 amino acids in length and functions as a transcriptional repression domain found in numerous transcription factors. Over 220 KRAB-zinc finger protein (KRAB-ZFP) genes have been identified in the human genome. These proteins repress transcription via interaction with KAP-1 (KRAB-associated protein 1), an 835 amino acid polypeptide containing a RING finger, B boxes, and a PHD finger.

KAP-1 forms complexes with KRAB-domain transcription factors to enhance repression efficiency. It interacts directly with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1), targeting KRAZ1 to centromeric heterochromatin containing HP1α to regulate transcriptional repression. Mutations in KAP-1 that disrupt HP1 binding lead to random KRAZ1 distribution and strong transcriptional activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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