Thermo Fisher Scientific CD10 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with rat based on sequence homology.

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates a variety of biologically active peptides.
CD10 is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells, immature B cells in adult bone marrow, and cells from patients with chronic myelocytic leukemia (CML).
It is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on the brush border of kidney and gut epithelial cells.
CD10 cleaves peptides at the amino side of hydrophobic residues, inactivating several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a >45 kb single-copy gene. The 5′ untranslated region is alternatively spliced, producing four mRNA transcripts without affecting the coding region.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.