Thermo Fisher Scientific SHANK3 Polyclonal Antibody
SHANK3 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 항체로, PBS와 50% glycerol에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SHANK3 (Accession Q9BYB0), corresponding to amino acid residues T750–S800 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900527 |
Product Specific Information
Antibody detects endogenous levels of total SHANK3.
Target Information
SHANK3 is a major scaffold postsynaptic density protein that interacts with multiple proteins and complexes to orchestrate dendritic spine and synapse formation, maturation, and maintenance. It connects receptors of the postsynaptic membrane, including NMDA-type and metabotropic glutamate receptors, via complexes with GKAP/PSD-95 and HOMER, and links to the actin-based cytoskeleton. SHANK3 plays a critical role in structural and functional organization of the dendritic spine and synaptic junction, interacting with Arp2/3 and WAVE1 complexes and promoting F-actin clustering. Through regulation of actin dynamics, SHANK3 contributes to neuron growth cone motility and NMDA receptor signaling, and modulates GRIA1 exocytosis and GRM5/MGLUR5 expression to control synaptic transmission and plasticity. It may be required at early stages of synapse formation and inhibited by IGF1 to promote synapse maturation. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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