Thermo Fisher Scientific CD30 Polyclonal Antibody
Human CD30 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:1,000–1:2,500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, PBS/glycerol buffer에 보존. Hodgkin 림프종 등 CD30+ 세포 연구에 적합.
- 카탈로그번호
- PA583219
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD30 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TNFRSF8 (CD30). Recombinant protein control fragment (Product #RP-102615). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790375 |
Product Specific Information
Immunogen sequence:
RCFFHSVCPA GMIVKFPGTA QKNTVCEPAS PGVSPACASP ENCKEPSSGT IPQAKPTPVS PATSSASTMP VRGGTRLAQE AASKLTRAPD SPSSVGRPSS DPGLSPTQPC P
Target Information
CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein of the TNF receptor superfamily.
Originally identified as a surface antigen of Hodgkin’s and Reed-Sternberg cells, CD30 binds CD30L (CD153) and mediates cell proliferation, differentiation, and apoptosis.
It plays a key role in Hodgkin’s disease and other CD30+ lymphomas and acts as a costimulatory molecule in thymic negative selection.
CD30 expression is observed in Hodgkin’s and Reed-Sternberg cells, certain non-Hodgkin’s lymphomas, virus-infected T/B cells, and activated normal T/B cells.
Soluble CD30 (sCD30) serves as a marker of Th2 immune response.
TRAF2 and TRAF5 interactions activate NF-κB signaling, regulating apoptosis and limiting autoreactive CD8 T cell proliferation.
Two alternatively spliced transcript variants encode distinct isoforms.
CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL), as well as embryonal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.