Thermo Fisher Scientific TRPC6 Polyclonal Antibody
TRPC6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Mouse와 Rat 시료에 반응하며, 합성 펩타이드를 면역원으로 제작되었습니다. 단백질 발현 연구 및 TRPC6 관련 질환 연구에 유용합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 3–10 µg/mL
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from TAA region 10–60 of rat TRPC6 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C (short term); for long-term, store at –20 °C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous with the corresponding sequence in mouse.
- Specificity: TRPC6.
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane, activated by diacylglycerol (DAG) and regulated via the phosphatidylinositol second messenger system. Activation occurs independently of protein kinase C and intracellular calcium levels.
Defects in the TRPC6 gene are associated with focal segmental glomerulosclerosis 2 (FSGS2).
TRPC6 belongs to the mammalian transient receptor potential (TRP) superfamily, specifically the canonical TRPC family. Members of this family are activated through PLC-coupled receptors and function as receptor-regulated cation channels. The TRPC3/6/7 subfamily can be activated by DAG analogs, suggesting a mechanism of activation via PLC-coupled receptors.
When expressed in transfected cells, TRPC6 acts as a non-selective, store-independent, receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and insensitive to IP3 activation.
TRPC6 is implicated in endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.