Thermo Fisher Scientific LGI4 Polyclonal Antibody
LGI4 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트에 반응합니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human LGI4 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The leucine-rich, glioma inactivated gene 4 (LGI4) belongs to the LGI family, in which LGI1 is the exemplar. This family consists of four highly related proteins containing leucine-rich repeats (LRRs), similar to transmembrane signaling molecules and receptors.
LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autosomal dominant lateral temporal epilepsy (ADTLE). Although LGI4 shares high homology and similar expression patterns with LGI1, mutations in LGI4 have not been linked to ADTLE. The LGI4 gene is located in a region associated with benign familial infantile convulsions, and certain polymorphisms have been correlated with childhood absence epilepsy. Reduced LGI4 expression has been shown to inhibit myelination in cultured cells, suggesting a role in neural development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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