Thermo Fisher Scientific Caspase 4 Polyclonal Antibody
Human Caspase 4 단백질을 인식하는 Rabbit Polyclonal Antibody. Western Blot 및 IHC(Paraffin)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 시약으로, 연구용 세포 사멸 관련 단백질 분석에 적합. 단기 4°C, 장기 -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 148–360 of Human Caspase 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.89 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2547262 |
Product Specific Information
- Recommended positive controls: H1299, K562, THP-1, HL-60, myc-tagged human caspase4-transfected 293T cells
- Predicted reactivity: Rhesus Monkey (96%), Bovine (84%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and large and small protease subunits. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme. Caspase 4 can cleave and activate its own precursor and caspase 1 precursor. Overexpression induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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