Thermo Fisher Scientific MYH7 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MYH7 for WB, ICC/IF, and ELISA. Recognizes MYH7/B-MHC (aa 1700–1800). Validated in human, mouse, and rat. Supplied as liquid, 0.16 mg/mL in PBS with 50% glycerol. Store at −20 °C, avoid freeze/thaw cycles.
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- PA5110000
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:500 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1700–1800 of human MYH7/B-MHC (NP_000248.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.16 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855411 |
Product Specific Information
Immunogen sequence: KKMDADLSQL QTEVEEA
Target Information
Muscle myosin is a hexameric protein containing two heavy chain subunits, two alkali light chain subunits, and two regulatory light chain subunits. The MYH7 gene encodes the beta (slow) heavy chain subunit of cardiac myosin, predominantly expressed in the human ventricle and in skeletal muscle rich in slow-twitch type I fibers.
Alterations in MYH7 expression correlate with cardiac contractile velocity and are affected by thyroid hormone depletion and hemodynamic overloading.
Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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