Thermo Fisher Scientific TCTN2 Polyclonal Antibody
TCTN2 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 1 mg/mL 액상 시약. 연구용으로만 사용.
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Thermo Fisher Scientific TCTN2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TCTN2, amino acids 61–160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not well known, it shares 49% similarity with TCTN1. TCTN1 is expressed during embryonic development in regions involved in Hh signaling, starting from gastrulation stages in the ventral node. Mutant TCTN1 mice die between E13.5 and E16.5, exhibiting holoprosencephaly associated with reduced Hh signaling, indicating TCTN1's role as an Hh activator. At later developmental stages, TCTN1 may also act as a repressor of the Hh pathway in the anterior and posterior neural tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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